Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.

The Cell Types and the Matrix

Hepatocytes
Signaling Pathways in Biliary Epithelial Cells
Stellate Cells
Signaling Pathways in Liver Diseases Kupffer Cells
Hepatic Sinusoidal Endothelial Cells
Extracellular Matrix
Platelets: A New Cell Type in Liver Physiology
Immune Cell Communication and Signaling Systems in Liver Disease
The Pathways
Toll-Like Receptors
TNF/TNF Receptors
Fas/FasL
Interferon Signaling
NF-?B
JNKs in liver diseases
Insulin Pathway
Role of PKB/Akt in Liver Diseases
Targeting mTOR Signaling Pathways in Liver Disease
AMP-Activated Protein Kinase in Liver
ER Stress Signaling in Hepatic Injury
PPAR?, A Key Regulator of Hepatic Energy Homeostasis in Health and Disease
Bile Acids and Their Receptors
Signaling Pathways in Liver Diseases: PXR and CAR
p53
The MYC Network and Cancer
The WNT/?-Catenin Pathway
Sonic Hedgehog Pathway
Hypoxia-Inducible Factor-1 Signaling System
VEGF Signaling
Apoptosis and Mitochondria
Calcium Signaling
HBV Signaling
Hepatitis C Virus and Insulin Signaling
MicroRNAs
Hepatic Clocks.