This book provides an interesting snapshot of recent advances in the field of single molecule nanosensing. The ability to sense single molecules, and to precisely monitor and control their motion is crucial to build a microscopic understanding of key processes in nature, from protein folding to chemical reactions. Recently a range of new techniques have been developed that allow single molecule sensing and control without the use of fluorescent labels. This volume provides an overview of recent advances that take advantage of micro- and nanoscale sensing technologies and provide the prospect for rapid future progress. The book endeavors to provide basic introductions to key techniques, recent research highlights, and an outlook on big challenges in the field and where it will go in future. It is a valuable contribution to the field of single molecule nanosensing and it will be of great interest to graduates and researchers working in this topic.

Part I Optical Sensing

Interferometric Biosensing
Optoplasmonic Whispering Gallery Mode Sensors for Single Molecule Characterization: A Practical Guide
Nonlinear Optical Microcavities Towards Single-Molecule Sensing
Part II Optomechanical Sensing
Optomechanical Sensing
Quantum Optical Theories of Molecular Optomechanics
Part III Biomolecular Manipulation
Dielectrophoresis of Single Molecules
Optical Trapping of Single Molecules
Applications of Trapping to Protein Analysis and Interactions
Towards Single-Molecule Chiral Sensing and Separation
Part IV Nanopores
Experimental Approaches to Solid-State Nanopores
Challenges in Protein Sequencing using 2-D MoS2 Nanopores
Single-molecule Ionic and Optical Sensing with Nanoapertures
Self-induced Back-action Actuated Nanopore Electrophoresis (SANE) sensing.