This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across  epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. 
The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.

1. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells

2. Na+-K+-2Cl- Cotransporter
3. Thiazide-sensitive NaCl Cotransporter
4. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia
5. Na+/H+ Exchangers in Epithelia
6. Sugar Transport Across Epithelia
7. Amino Acid Transporters of Epithelia
8. Structure-Dynamic and Regulatory Specificities of Epithelial Na+/Ca2+ Exchangers (NCX)
9. Urea Transporters in Health and Disease
10. H,K-ATPases in Epithelia
11. Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells
12. Properties, Structure and Function of the Solute Carrier 26 Family of Anion Transporters
13. ClC-2 Chloride Channels
14. The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology
15. CFTR and Cystic Fibrosis: A Need for Personalized Medicine
16. Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator
17. TMEM16 Proteins (Anoctamins) in Epithelia
18. Epithelial Sodium Channels (ENaC)
19. ROMK and Bartter Syndrome Type 2
20. Inwardly-rectifying K+ channel 4.1 regulates renal K+ excretion in the aldosterone-sensitive distal nephron
21. Small-molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels
22. KCa3.1 in Epithelia
23. BK Channels in Epithelia
24. Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ channels
25. KCNE regulation of KCNQ channels
26. Orai Channels
27. Trp Channels in Renal Epithelia
28. P2X receptors in Epithelia
29. The Polycystins and Polycystic Kidney Disease
30. Renal Aquaporins in Health and Disease.