The purpose of this book is to provide a broad scope of substance use disorder research and how these findings can impact treatment outcomes. The research and outcomes described in this book represent important principles related to identifying and understanding factors related to substance use disorders. The first section is dedicated to methodology including population-based surveys, basic neuroanatomy, chemistry, molecular biology, behavioral models and brain imaging. The second section utilizes this methodology in research related to opioids, cocaine, marijuana, alcohol and nicotine. The book is aimed at both professionals (academics, clinicians, practitioners) and students or trainees.

1. Methods for Population Research on Substance Use and Consequences

2. Translational Molecular Approaches  in Substance Abuse Research
3. Small Molecule Neuropeptide-S and Melanocortin  Receptor Ligands  As Potential Treatments for Substance Use Disorders
4. Emerging Insights into Mu Opioid Pharmacology
5. Behavioral Pharmacology of Drugs Acting at Mu Opioid Receptors
6. The Rise and Fall of Kappa-Opioid Receptors in Drug Abuse Research
7. Clinical Trials for Opioid Use Disorder
8. Modelling Differential Vulnerability  to Substance Use Disorder in Rodents:  Neurobiological Mechanisms
9. Activity-Dependent Epigenetic Remodeling  in Cocaine Use Disorder
10. Molecular Mechanisms of Amphetamines
11. Clinical Trials for Stimulant Use Disorders:  Addressing Heterogeneities That May  Undermine Treatment Outcomes
12. Molecular Mechanism and Cannabinoid  Pharmacology
13. Pharmacotherapies for Cannabis Use Disorders:Clinical Challenges and Promising Therapeutic Agents
14. Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence
15. Randomized Clinical Trials Investigating Innovative Interventions for Smoking Cessation in the Last Decade
16. Adolescent Vulnerability to Alcohol Use  Disorder: Neurophysiological Mechanisms  from Preclinical Studies
17. Medication Development for Alcohol Use  Disorder: A Focus on Clinical Studies
18. Newly Emerging Drugs of Abuse.