Targeted intraoperative radiotherapy is a major advance in the management of cancer patients and has been attracting massive interest worldwide following publication of the results of an important randomized controlled trial in The Lancet. This textbook is designed to introduce this innovative technology in a comprehensive manner to clinicians dealing with cancer patients. Throughout, the emphasis is on practical aspects and the text is supported by many excellent illustrations. The editors of the book have extensive experience in targeted intraoperative radiotherapy and include co-directors of the TARGIT Academy, which runs international training courses on the technology in the United Kingdom and Germany. They have brought together multidisciplinary contributors from different centers across the world who have wide experience in the field and whose work has been recognized internationally. It is the editors' hope that this book will succeed in ensuring that targeted intraoperative radiotherapy is used effectively worldwide.

Concept and review of the evidence

Mechanism of Action of TARGIT
How to use Intrabeam
Quality Assurance and Commissioning
Radiation protection
Radiobiology of TARGIT
Surgical aspects of TARGIT Technique in Breast Cancer
Follow-up findings in the tumour bed after IORT- What the Radiologist needs to know
Quality of life and late radiation toxicity
Cosmetic outcome following TARGIT
Targeted Intraoperative Radiotherapy and Persistent Pain After Treatment
Other applications
ö Intraoperative Photon Radiosurgery in Patients with Malignant Brain Tumours
Intraoperative radiotherapy with low-energy photons in rectal cancer recurrence
Cases
Experience with TARGIT in a Developing Country
TARGIT Trials and what to tell the patients
Quality Assurance and Training of Targeted Intraoperative Radiotherapy: Establishment of the TARGIT Academy
Health economics.