1;Preface;5 2;Contents;6 3;List of Contributors;9 4;Prediction of Tumor Behavior;13 4.1;Beyond Typing and Grading: Target Analysis in Individualized Therapy as a New Challenge for Tumour Pathology;14 4.2;Oncogenic Signaling Pathways and Deregulated Target Genes;18 4.3;Predictive Pathology of Cytostatic Drug Resistance and New Anti- cancer Targets;36 4.4;Prediction of Response to Neoadjuvant Chemotherapy in Carcinomas of the Upper Gastrointestinal Tract;44 4.5;Resistance-Associated Signatures in Breast Cancer;48 4.6;Resistance to Chemotherapy in Ovarian Carcinoma;62 4.7;Clinical, Biological, and Molecular Aspects of Metastasis in Colorectal Cancer;72 4.8;Prediction of Efficacy and Side Effects of Chemotherapy in Colorectal Cancer;92 4.9;Proteomic Expression Profiling of Breast Cancer;100 5;Targeted Therapy and Clinical Applications;132 5.1;Targeted Therapy and Blood- Brain Barrier;133 5.2;Cetuximab: Appraisal of a Novel Drug Against Colorectal Cancer;144 5.3;C- kit, GIST, and Imatinib;153 5.4;Antibody Therapy in Non- Hodgkin's Lymphoma: The Role of Rituximab, 90Y- Ibritumomab Tiuxetan, and Alemtuzumab;160 5.5;Molecular and Clinical Aspects of Proteasome Inhibition in the Treatment of Cancer;171 5.6;Individualized Target Therapy of Malignant Lymphomas: An Outlook;183 5.7;Antiangiogenesis, Anti-VEGF( R) and Outlook;195 5.8;Morphological Detection of Hormone and Growth Factor Receptors in Breast Cancer;206 6;Prospects for Development;215 6.1;Antigen- Specific Cancer Vaccines;216 6.2;Therapeutic Vaccination for the Treatment of Malignant Melanoma;222 6.3;Monoclonal and Recombinant Antibodies with T Cell Receptor- Like Reactivity;231 6.4;New Molecular Therapy Targets in Acute Myeloid Leukemia;244