This textbook provides a practically applicable resource for understanding the surgical oncology management of pancreatic cancer. It discusses relevant aspects of anatomy and pathophysiology along with the latest diagnostic techniques. Insightful descriptions are then provided detailing how to perform critical surgical procedures when treating these patients.  Relevant perioperative management strategies and emerging themes in cancer biology critical to understanding and treating the disease are also described.

The need for cross-discipline collaboration to facilitate and enhance innovation within the discipline is reinforced throughout the text. Each chapter presents the relevant current clinical standards along with areas of controversy in both research and clinical practice within "pearls and pitfalls" sections.

Textbook of Pancreatic Cancer: Principles and Practice of Surgical Oncology is a detailed work covering the basic material important to trainees as well as advanced curriculum for established specialists in the field from a multi-disciplinary perspective. Therefore, it is crucial resource for all practicing and trainee professionals who encounter these patients in their day-to-day clinical practice. 

Section 1 defining the disease burden

Pancreatic cancer in the population
Pancreatic cancer biology
Pancreatic cancer precursors (pancreas cysts)
Genetic syndromes and screening
PDAC pathways
Centralization of surgery and volume-outcome issues
Education & training in pancreatic surgery
research and progress in pancreatic surgery
Section 2 Anatomy and physiology  
Anatomy and embryology
Anatomical variants
Vascular supply - Important arterial and venous variants
Lymphatic drainage and variants
 Section 3 Symptoms and presentation (with pathophysiology)
Intro: PDAC as a difficult disease to diagnose
Jaundice
cachexia and sarcopenia
pain
diabetes (new onset diabetes) Section 4 Imaging and preoperative staging
Intro: goals of imaging /staging
CT - protocol, pearls and pitfalls; resectable/borderline; locally advanced
imaging after neoadjuvant therapy
MRI - protocol, added value, cancer, cysts, accuracyetc
 Standard for reporting imaging results
EUS - cancer, cysts, FNAC, biopsy, sens/spec, accuracy, markers
ERCP - indications, stenting
MDT - multidisciplinary team meeting; tumor board
when a diagnosis can not be confirmed
Section 5 Pathology and laboratory - reporting and research
Intro: personalized medicine and precision medicine
gross pathology - important aspects and standards
histopathology - important aspects and standard template
tissue sampling for research - fresh frozen
sampling from formalin fixed tissue- aspects
tumor markers (and biomarker research)
blood samples for research - liquid biopsy, proteomics etc
Genomics, NGS, molecular classification
Section  6 Chemotherapy and radiation therapy
history of chemoradiotherapy in PDAC
Available drugs - mechanisms, effect and side-effects
role and mechanisms of radiotherapy
Adjuvant chemotherapy - best evidence
Neoadjuvant treatment in upfront resectable - principles and ongoing trials
NAT in borderline or locally advanced - indiuction chemo
Use of organoid modles to monitor/choose chemotherapy
something here on novel therapies: immunotherapy etc? Section 7 Perioperative management
Anesthesia and peri-op  management
Enhanced recovery - principles and standards
Nutritional support and therapy in pancreatic surgery
use of drains
use of high-dependency unit/ICU/ward
 Section  8 Surgery
Intro: Surgery as a curative apporach to PDAC
Surgery for pancreatic head cancers
Surgery for body and tail cancers
central resections and enucleations
Artery-first approach
Minimal invasive pancreatic surgery
Venous resection
Arterial resection
Reconstruction techniques, variations
DP-CAR
Extended resection criteria - multiorgan, M1 disease etc
total pancreatectomy
Lymphadenecomty
Should we resect PDAC with solitary metastatis (liver, lung)
Research gaps.