This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are  diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons.

This book covers a wide range of topics and provides  an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge  organized  in concise and structured chapters, with key points and pertinent references.  The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease).

The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows  and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Part 1: Anatomy and Physiology

Chapter 1: Anatomy and Pharmacology of Vessels
Chapter 2: Physiology of Vessels
Chapter 3: Cell Biology of Vessels
Chapter 4: Stem Cell Biology and the Cardiovascular System
Chapter 5: The Lymphatic System
Chapter 6: Imaging the vascular wall; from microscope to virtual reality
Chapter 7: Clinical Cardiovascular Imaging
Part 2: Pharmacology and Signalling
Chapter 8: Vascular Signalling
Chapter 9: Vasoactive Peptides: Renin Angiotensin System
Chapter 10: Aldosterone
Chapter 11: Nitric Oxide
Chapter 12: Reactive Oxygen Species
Chapter 13: TGF-beta in Vascular Pathobiology
Chapter 14: miRNA and IncRNA in the Vascular System
Chapter 15: Microparticles and Exosomes in Cell-Cell Communication
Part 3: Pathophysiology of Vascular Diseases
Chapter 16: Genomics of Hypertension
Chapter 17: Endothelial Dysfunction
Chapter 18: Vascular Remodelling
Chapter 19: Vascular Stiffness
Chapter 20: Atherosclerosis
Chapter 21: Inflammation and Immunity in Vascular Diseases
Chapter 22: Diagnostic and therapeutic targeting of inflammation
Chapter 23: Perivascular Adipose Tissue
Chapter 24: Vascular Biology of Chemotherapeutic Drugs
Chapter 25: Coronary Microvascular Disease
Chapter 26: Cerebral Small Vessel Disease and Vascular Cognitive Impairment: Preclinical Aspects
Chapter 27: Ethnicity and Cardiovascular Disease
Part 4: Clinical Aspects
Chapter 28: Epidemiology of Vascular Diseases
Chapter 29: Early Vascular Ageing and Healthy Vascular Ageing
Chapter 30: Biomarkers of Cardiovascular Disease
Chapter 31: Hypertension
Chapter 32 Diabetic Retinopathy
Chapter 33: Ischaemic Heart Disease
Chapter 34: Pre-eclampsia
Chapter 35: Stable Coronary Artery Syndromes
Chapter 36: Heart Failure: HFrEF
Chapter 37 Heart Failure: HFpEF
Chapter 38 Renal Disease
Chapter 39 Obesity
Chapter 40 Diabetes
Chapter 41 Pulmonary
Hypertension
Chapter 42 Cerebral Small Vessel disease and Vascular Cognitive Impairment
Chapter 43 Stroke
Chapter 44 Peripheral Vascular Disease
Chapter 45 Vascular malformations and tumours.