The Biology of Germinal Centers in Lymphoid Tissue

The Biology of Germinal Centers in Lymphoid Tissue

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This book meets the demand of a recent surge of interest in germinal centers, the foci of antigen-induced, rapidly proliferating B lymphocytes, representing sites in mammalian lymphoid tissue where memory B cells are generated. Various aspects of the generation of germinal centers, the somatic hypermutation process and the cellular interactions involved in the selection process are discussed in detail. A chapter on germinal center-derived lymphomas completes the treatment.

1. Overview of Germinal Center Function and Structure in Normal and Genetically Engineered Mice
2. The Germinal Center Reaction: Influence of FDC Function in Normal, Aged, and Retrovirus Infected Hosts
3. T and B Lymphocytes in Germinal Centers
4. Somatic Hypermutation of Immunoglobulin Genes
5. Germinal Center Derived Lymphomas in Humans and Mice
Color Figures.
ISBN 978-3-662-13143-5
Artikelnummer 9783662131435
Medientyp Buch
Auflage Softcover reprint of the original 1st ed. 1998
Copyrightjahr 2013
Verlag Springer, Berlin
Umfang XI, 241 Seiten
Abbildungen XI, 241 p. 21 illus., 6 illus. in color.
Sprache Englisch