This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the 'disease-related' chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where 'modern' technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.

<b>Chapter 1: </b>Li-Fraumeni Syndrome<p><b>Chapter 2: </b>Pediatric Central Nervous System Cancer Predisposition<b></b></p><p><b>Chapter 3:</b> Rhabdoid Tumors</p><p><b>Chapter 4:</b> Neurofibromatosis</p><p><b>Chapter 5:</b><b><i> </i></b>Pheochromocytoma and Paraganglioma syndromes<b></b></p><p><b>Chapter 6: </b>Wilms tumor<b></b></p><p><b>Chapter 7: </b>Hereditary Overgrowth Syndromes<b></b></p><p><b>Chapter 8: </b>Multiple Endocrine Neoplasias and Associated Non-Endocrine Conditions<b></b></p><p><b>Chapter 9: </b>DICER1 Syndrome<b></b></p><p><b>Chapter 10: </b>Cancer-prone Inherited Bone Marrow Failure, Myelodysplastic and Acute Myeloid Leukemia Syndromes<b></b></p><p><b>Chapter 11: </b>Inherited Risk for Childhood Leukemia</p><p><b>Chapter 12: </b>Inherited pediatric cancer in low and intermediate resource countries<b></b></p><p><b>Chapter 13:</b><b> </b>Frontline Ethico-legal Issues in Childhood Cancer Genetics Research<b></b></p><p><b> </b></p><p><b>Chapter 14: </b>Genetic counseling and testing</p><p><b>Chapter 15: </b>Psychosocial aspects of childhood cancer genetics<b></b></p><p><b>Chapter 16: </b>Recognition of cancer predisposition syndromes</p>