The means by which proteins and RNAs are exchanged between cytoplasm and nucleus have interested cell biologists for many years, and the field has seen a number of exciting recent advances. Much has been learned about the intricate architecture of the nuclear pore-complex, the mechanisms by which transport substrates are sorted, and the supply of energy for exchange processes. This book attempts a general review of the growing body of knowledge. However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.

1. Perspectives in Transport

2. The Vagaries of Diffusion
3. Cellular Structures and Nucleocytoplasmic Transport
4. Events at the Pore-Complex
5. Events Involving the Nucleoskeleton and Cytoskeleton
6. Regulation and Pathologies of Nucleocytoplasmic Transport
7. Evaluation of a Model.