This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.

Part I: The Human Microbiome

Overview of the Human Microbiome
Methods in Microbiome Studies: Collection
Methods in Microbiome Studies: Informatics
Part II: Immunogenetics of the Host Response to Infection
Immunodeficiency and Autoimmunity
Immunology of the Microbiome
Lessons Learned from Animal Models on the Role of the Microbiome in Autoimmunity
The Stroma in Chronic Inflammation
Part III: Infections Agents
Borrelia Burgdorferi
Helicobacter Pylori
Chlamydiae: Chlamydia Trachomatis and C. Pneumonia
Mollicutes: Mycoplasma Pneumonia
Role of Infection in Protection from Autoimmunity
DNA Viruses
RNA Viruses
Human Immunodeficiency Virus Infection
Enteroviruses
Hepatitis A Virus
Hepatitis C Virus
Protozoal Infections
Helminth Infections
The Case for Fungi as Triggers for Autoimmunity
Part IV: The Role of Infectious Agents in Rheumatic Diseases
RA
Spondylitis
JIA
Psoriasis & PSA
Inflammatory Bowel Disease
Reactive Arthritis
Rheumatic Fever / Post-Streptococcal Glomerunlonephritis
SLE
APS
Sjorgren's Syndrome
Myositis
Vasculitis Syndromes
Cryoglobulinemia
Behcet's
Uveitis
Sarcoidosis
Autoinflammatory Syndromes
Miscellaneous
Part V: Practical Aspects
Vaccinations in Rheumatology
Management of Autoimmune Disorders During Infection / Immunodeficiency
Individual Drugs in Rheumatology and the Risk of Infection
The Microbiome: Towards Individualized Medicine