The Myc/Mad/Mad network is defined by, and functions through, the interactions between individual Myc and Mad family proteins with Max as well as by interactions between Myc and Mad family proteins with higher order co-repressor and co-activator complexes.The chapters included in this volume illustrate the complexities of the Myc/Max/Mad network and how its functions impinge on fundamental biological processes through regulation of transcription.

Preface

Making Myc
Transcriptionsl Activation by the Myc Oncoprotein
Mechanisms of Transcriptional Repression by Myc
The Mad Side of the Max Network: Antagonising the Function of Myc and More
Structural Aspects of Interactions within the Myc/Max/Mad Network
Myc Target Transcriptomes
c-Myc, Genome Instability, and Tumorigenesis: The Devil is in the Details
Lessons Learned from Myc/Max/Mad Knockout Mice
Myc/Max/Mad in Invertebrates. The Evolution of the Max Network
The Mix Network: Evidence for a Parallel Max-like Transcriptional Network that Regulates Energy Metabolism
Subject Index