As in other volumes in the series, this newest volume conveys up-to-date knowledge in a clear and straightforward manner. It begins with a survey of the neurobiological functions of the brain, with the emphasis on Parkinson's disease. This is followed by a presentation of the role of dopamine in the regulation of human anterior pituitary function. The final two chapters concentrate on the dopamine receptors: first, the binding sites are characterized and the biochemical and physiological consequences of dopamine-receptor stimulation are discussed and, finally, there is a report on the topology of a dopamine-receptor model that can account comprehensively for agonists and antagonists.

The Role of Dopamine in the Control of Neurobiological Functions

Parkinson's Disease
Senile Dementia of the Alzheimer Type
A DA Hypothesis of Schizophrenia
DA in Affective Disorders
References
Clinical Aspects of Dopamine in the Regulation of Human Anterior Pituitary Function
Regulation of Prolactin Secretion
Clinical Features of Hyperprolactinaemia
Diagnosis of Hyperprolactinaemia
Natural History of Prolactinomas
Therapy
Macroprolactinomas
Dopamine and LH Secretion
Dopamine in Growth Hormone Secretion
Dopamine Agonist Therapy for Acromegaly
Dopamine and ACTH Secretion
Conclusions
References
Dopamine Receptors in the Central Nervous System
Receptors and Second Messengers
Second Messengers and Dopamine Receptors
Binding Sites for Dopamine Receptor Ligands
Biochemical and Physiological Manifestations of Dopamine Receptor Stimulation
Behavioural Manifestations of Dopamine Receptor Stimulation
Conclusions
References
Topology of Dopamine Receptors
Dopamine Agonists
Dopamine Antagonists
Unsolved Problems: D1/D2 Specificity and Partial Agonists
Conclusion
References.