This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation.

Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.

Robert Clarke, PhD, DSc, FRSBiol, FRSChem, FRSMed is Professor of Oncology at Georgetown University (Washington, DC, USA). He is Dean for Research at Georgetown University Medical Center (GUMC), home to over 80% of sponsored research at Georgetown University. Dr. Clarke is also Director of the Biomedical Graduate Research Organization, one of four academic units within GUMC. A member of the Georgetown-Lombardi Comprehensive Cancer Center, he is currently Co-Leader of the Breast Cancer Program.

Dr. Clarke earned a DSc in 1999, a PhD in 1986, and a MSc in 1982 (each in Biochemistry) from the Queen's University of Belfast, Northern Ireland, and a BSc (Biological Sciences) in 1980 from the University of Ulster, Northern Ireland. He completed his postdoctoral training as a Breast Cancer Study Group Fellow with Dr. Marc E. Lippman at the National Cancer Institute (National Institutes of Health, Bethesda, MD, USA). In 1989, Dr. Clarke joined the Department of Physiology & Biophysics at Georgetown University. He served as Secretary/Treasurer of the Georgetown University Faculty Senate from 2004-2007.