This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics - the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.

From the contents: Ge-68/Ga-68 generators

Automation strategies in Ga-68 radiopharmaceutical preparations
Post-processing via cation exchange cartridges
Gallium-68 generator integrated system: elution - purification - concentration integration
Purification and labelling strategies for 68 Ga from 68 Ge/ 68 Ga generator eluate
67 Ga and 68 Ga purification studies
The diversity of [ 68 Ga]Ga-based imaging agents
Nanoparticles and phage display selected peptides for imaging and therapy of cancer
"Click" cyclized gallium-68 labeled peptides for molecular imaging and therapy: Synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system
Early experience with 68 Ga-DOTATATE preparation
68 Ga-radiopharmaceuticals for PET imaging of infection and inflammation
68 Ga-labeled bombesin analogs for receptor mediated imaging
A novel 68 Ga-labelled pteroic acid-based PET tracer for tumour imaging via the folate receptor
Measurement of protein synthesis: In vitro comparison of 68 Ga-DOTA-puromycin, [ 3 H]tyrosine and 2-fluoro-[ 3 H]tyrosine
Hypoxia imaging agents labeled with positron emitters
Lu-177/Y-90 intermediate affinity monoclonal antibodies targeting EGFR and HER2/c-neu: preparation and preclinical evaluation
Divergent role of 68 Ga labeled somatostatin analogs in the work-up of patients with NETs
Differential uptake of 68 Ga-DOTATOC and 68 Ga-DOTATATE in PET/CT of gastroenteropancreatic neuroendocrine tumours.