In the past few years nucleic acids technologies have grown into a powerful analytical and also increasingly therapeutic tool. It has been applied not only to the uncovering of gene functions in many organisms, but also to pathogenetic analysis and recently also for the treatment of human diseases. The book discusses in depth the potential of these innovative methods in the broad field of central nervous system and brain tumours particularly. Whereas there is currently no comprehensive overview on potential and challenges of nucleic acids technologies for basic brain tumours and for the clinical management of patients with brain tumours, this book does explicitly cover the many other aspects of the "RNA World" (pathogenic and therapeutic potential of microRNAs, aptamer technology, etc.), too. With this significantly broadened scope as compared to currently existing books it appears to be an urgently needed new publication.

Molecular Biology of Malignant Gliomas

Molecular Neurooncology and Neoangiogenesis of Malignant Gliomas
Molecular Therapies for Malignant Gliomas
Novel Strategies for the Treatment of Brain Cancer
Gene Therapy for Malignant Glioma
Immunotherapeutic Approach for Glioma by Alphaviruses as Positive Strand RNA Viruses
Diagnosis of Brain Tumors Through Global Specific DNA Methylation Analysis
Molecular Markers of Gliomas
Microarray and Proteomic Analysis of Gliomas: Target Strategies
Nanosystems for the Delivery of RNAi
Interference RNA Intervention in Brain Tumors
Blood-Brain Barrier Transport for RNAi
Therapeutic Potential of Small Interfering RNA for Brain Diseases
RNA Interference-Based Therapies Against Brain Tumors: Potential Clinical Strategies
MicroRNA: Biogenesis, Regulation, and Role in Primary Brain Tumors
Treatment of High-Grade Gliomas in Adults
Treatment of Malignant Gliomas with Antisense Oligonucleotides
Suppression of EGFR Expression by Antisense RNA and RNAi
Brain Tumor Therapy with Antisense Oligonucleotides
Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System
The Non-Coding Oncofetal H19 Gene in Brain Tumors.