In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies - including multicenter studies - have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely.
This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects - kidney, hormonal pathways systems, brain, muscle, etc - of altered TH metabolism in HF, as well as the clinical and prognostic implications. The  section devoted to the potential  therapeutic treatments has been expanded.
Thanks to its translational approach to this highly complex subject, the book will be  of interest to a broad readership, including cardiologists, endocrinologists and internists. 

<p>I Heart Failure and thyroid dysfunction: General Aspects

1 Thyroid heart interaction: hystorical perspectives
2 Epidemiology of Heart Failure
3 Heart Failure, overt and subclinical thyroid dysfunction
4 Thyroid, Heart Failure and Cardioprotection
II Heart and Thyroid in Normal and Failed Heart: Basic Aspect
5 Mechanism of Action of TH on the Cardiovascular System
6 Novel insights into the machinery controlling the cellular response to TH
7 Thyroid Hormone Receptor Signaling
8 Thyroid Hormone Deiodinative pathways in the normal and Failing Heart
9 3-Iodothyronamine mediated TH Metabolism in the Normal and Failing Heart
10 Cardiac Myocyte and Vascular Remodeling in altered and normalized TH metabolism
11 Thyroid Hormone and Mithocondrial Function and Protection in Normal and Failing Heart TH-Linked Epigenetic Factors in Heart Failure
12 TH-Linked Genetic Expression in Heart Failure
III Heart Failure and Thyroid in clinics
13 Thyroid and CardiovascularRisk
14 TH abnormalities and systolic and diastolic function
15 Heart Failure Drugs and influences on TH Metabolism
16 The complex relationship between TH, Kidney and Heart
17 TH, Brain and Heart
18 Thyroid, Heart Failure and Neuroendocrine Activation
19 Thyroid, Heart Failure, oxidative stress and inflammation
IV TH Treatment in Cardiac Disorders: Current and new perspectives
20 Thyroid hormone modalities of administration vs blood and tissue levels
21 TH treatment in patients with cardiac disorders: general aspects
22 TH analogs in Heart Failure: from the past to new perspectives
23 TH Treatment in AMI
23 TH Treatment in HF
24 TH Treatment in non-HF cardiac disorders
25 New approaches to normalize TH profile in HF</p>