For years, toxoplasmosis has been known as disease mostly affecting newborns. Since immunocompromised patients (AIDS) present a high risk of reactivation of chronic toxoplasmosis this parasitic disease has gained increasing interest. Besides presenting clinical and therapeutical concepts, this volume provides current knowledge about genetics and immunology of T. gondii and the interaction with its 'host'. Since in vivo and in vitro models of toxoplasmosis exist, and genetic manipulation has become possible, this protozoan parasite has recently been accepted as a model for understanding the pathogenesis and persistance of other intracellular parasites. The articles of the book compromise both reviewing current concepts and reporting on yet unpublished results of leading scientists in this field.

A Population Structure of Toxoplasma gondii: Implications of Clonality

Genetic Basis of Pathogenicity in Toxoplasmosis
DNA Polymorphisms Associated with Murine Virulence of Toxoplasma gondii Identified by RAPD-PCR
Biodiversity in Toxoplasma gondii
B The Parasite: From Antigens to Genes
The Major Surface Proteins of Toxoplasma gondii: Structures and Functions
Toxoplasma gondii Microneme Proteins: Gene Cloning and Possible Function
Role of Secretory Dense Granule Organelles in the Pathogenesis of Toxoplasmosis
Serological Recognition of Toxoplasma gondii Cyst Antigens
Toxoplasma gondii: Kinetics of Stage-Specific Protein Expression During Tachyzoite-Bradyzoite Conversion in Vitro
Bradyzoite-Specific Genes
C The Host: Immunogenetics and Immune Response
Immunogenetics in Pathogenesis of and Protection Against Toxoplasmosis
Cells and Cytokines in Resistance to Toxoplasma gondii
Role of Macrophage-Derived Cytokines in the Induction and Regulation of Cell-Mediated Immunity to Toxoplasma gondii
Role of Nitric Oxide-Induced Immune Suppression in Toxoplasmosis During Pregnancy and in Infection by a Virulent Strain of Toxoplasma gondii
Cytokine Production by Human Cells after Toxoplasma gondii Infection
Characterization of Human T Cell Clones Specific for Toxoplasma gondii
Toxoplasma Proteins Recognized by Protective T Lymphocytes
Immunological Control of Toxoplasma gondii and Appropriate Vaccine Design
D Diagnosis and Treatment of Toxoplasmosis
Detection of IgA anti-P30 (SAG1) Antibodies in Acquired and Congenital Toxoplasmosis
AIDS-Associated Cerebral Toxoplasmosis: An Update on Diagnosis and Treatment
Co-infection of Toxoplasma gondii with Other Pathogens: Pathogenicity and Chemotherapy in Animal Models
Influence of AntimicrobialAgents on Replication and Stage Conversion of Toxoplasma gondii
Molecular Genetic Tools for the Identification and Analysis of Drug Targets in Toxoplasma gondii
Studies of the Effect of Various Treatments on the Viability of Toxoplasma gondii Tissue Cysts and Oocysts.