This book provides comprehensive information on transcatheter aortic valve implantation (TAVI), which was introduced for the treatment of aortic valve disease less than two decades ago. It explains how TAVI has delivered satisfactory results even in high and intermediate risk patients and outlines how it continues to evolve, thus requiring awareness of state of the art approaches to indication, risk stratification, device choice, procedure, and follow-up. In addition, it reports on the complex and multidisciplinary approach needed to maximize the efficacy, safety, and appropriateness of TAVI, providing detailed clinical, interventional and surgical perspectives focusing on the development of this cardiovascular intervention.

Starting with the history of TAVI, addressing the interventional anatomy of aortic valve disease, and reporting on the expert authors' day-to-day experiences, this highly informative book offers an essential update for all cardiologists and surgeons interested in transcatheter aortic valve implantation, as well as any clinician, decision-maker and stakeholder involved in patient selection, procedural management, and follow-up.

I - Pathophysiological and translational perspectives

1 History of transcatheter aortic valve implantation
2 Interventional anatomy of aortic valve disease
3 Pathophysiology of aortic
4 Pathophysiology of aortic regurigation
5 Pathophysiology of degenerated bioprosthesis
6 Role of inflammation in native and prosthetic aortic valve disease
7 Predictive computational models of transcatheter aortic valve implantation
8 Hemodynamic issues with transcatheter aortic valve implantation
9 Risk scores for aortic valve
II Clinical perspectives
10 Role of rest and stress echocardiography in  transcatheter aortic valve implantation
11 Role of computed tomography in transcatheter aortic valve implantation
12 Role of magnetic resonance imaging in transcatheter aortic valve implantation
13 Concomitant coronary artery disease and aortic stenosis
14 Comparison of transcatheter aortic valve implantation to medical therapy in prohibitive risk patients
15 Clinical and imaging follow-up after transcatheter aortic valve implantation
16 Biomarkers before, during and after transcatheter aortic valve implantation
17 Prognostic impact of aortic regurgitation and paravalvular leak
18 Leaflet motion abnormalities
19 Gender-related differences in transcatheter aortic valve implantation
20 Implementation issues for transcatheter aortic valve implantation: cost-effectiveness, wait-times and volume-outcome balance
III Interventional perspectives
21 Transfemoral access management for transcatheter aortic valve implantation
22 Challenging anathomy for transcatheter aortic valve implantation
23 Abbott Vascular program for transcatheter aortic valve implantation
24 Boston Scientific program for transcatheter aortic valve implantation
25 Edwards program for transcatheter aortic valve implantation
26 JenaValve program for transcatheter aortic valve implantation
27 Medtronic program for transcatheter aortic valve implantation
28 Self-expanding vs balloon-expandable devices for transcatheter aortic valve implantation
29 Individualized device choice for transcatheter aortic valve implantation
30 Predilation for transcatheter aortic valve implantation
31 Postdilation for transcatheter aortic valve implantation
32 Embolic protection devices for transcatheter aortic valve implantation
33 Antithrombotic therapy during and after transcatheter aortic valve implantation
34 Contrast induced nephropathy and transcatheter aortic valve implantation
35 Conduction disorders and permanent pacemaker requirement after transcatheter aortic valve implantation
36 Systolic dysfunction and hemodynamic support in patients candidate for transcatheter aortic valve implantation
37 Radiation exposure in transcatheter aortic valve implantation
38 Procedure efficiency in transcatheter aortic valve implantation
39 Predictors of success for transcatheter aortic valve implantation
40 Learning curve, procedural volumes and relationship with clinical outcomes for transcatheter aortic valve implantation
41 Aortic valvuloplasty as bridge vs destination therapy
IV Surgical perspectives
42 Role of the heart team in decision making for transcatheter aortic valve implantation
43 Alternative accesses for transcatheter aortic valve implantation
44 Comparison of transcatheter aortic valve implantation to surgery in intermediate risk patients
45 New approaches for aortic valve disease: from transcatheter aortic valve implantation to sutureless aortic valves
46 Hybrid procedures for aortic valve disease: transapical aortic valve implantation through lower left anterior mini-thoracotomy vs Edwards Intuity valve implantation through upper right anterior mini-thoracotomy
V Future perspectives
47 Medical treatment for aortic valve disease
48 Transcatheter aortic valve implantation for pure aortic regurgitation
49 New-generation devices for transcatheter aortic valve implantation
50 Bioresorbable valve for transcatheter aortic valve implantation: tomorrow's world from preclinical to clinical
51 Focus on transcatheter aortic valve implantation in low risk patients
52 Conclusion.