This book provides comprehensive information on transcatheter aortic valve implantation (TAVI), which was introduced for the treatment of aortic valve disease less than two decades ago. It explains how TAVI has delivered satisfactory results even in high and intermediate risk patients and outlines how it continues to evolve, thus requiring awareness of state of the art approaches to indication, risk stratification, device choice, procedure, and follow-up. In addition, it reports on the complex and multidisciplinary approach needed to maximize the efficacy, safety, and appropriateness of TAVI, providing detailed clinical, interventional and surgical perspectives focusing on the development of this cardiovascular intervention.

Dr. Giordano completed his medical and cardiology training at the University of Naples, Italy, and has been an invasive cardiologist for more than 30 years. He currently directs the Interventional Cardiology Unit of Pineta Grande Hospital in Castel Volturno, and the Invasive Cardiology Unit of S. Lucia Hospital in S. Giuseppe Vesuviano, both in Italy. He is an internationally recognized expert in structural heart disease, leading one of the busiest structural heart disease centers in Europe, and also masters many techniques for transcatheter management of cardiac valvular disease, with an expertise ranging from new-generation devices for transcatheter aortic valve implantation to endovascular procedures and mitral valve repair. He has published several important articles on transcatheter aortic valve implantation, with a key focus on new devices, techniques, and methods to increase the biocompatibility of endoprostheses.

Prof. Biondi-Zoccai received his medical diploma from the University of Milan, Italy, completed his cardiology training at the Catholic University of Rome, Italy and refined his statistical expertise with an MStat diploma at the Tor Vergata University, Rome. He subsequently engaged in additional training at Hopital Hautepierre, Strasbourg, France, Hammersmith Hospital, London, UK, and Mount Sinai Medical Center, New York, USA. He is currently an Associate Professor of Cardiology at Sapienza University of Rome, and is an accomplished interventional cardiologist and clinical researcher, with a specific focus on outcome research. He has published more than 700 scholarly articles and edited 3 textbooks on clinical outcomes and research methodology.

Prof. Frati completed his medical training at Sapienza University of Rome, and subsequently his cardiac surgery training at Campus Biomedico University of Rome, Italy. He is currently a Full Professor and Staff Cardiac Surgeon at Sapienza University of Rome. He uniquely combines expertise in clinical and surgical practice with translational and clinical research skills. He has also worked extensively on stem cells and tissue engineering at Thomas Jefferson University, Philadelphia, USA, and the University of Paris, France. He has authored more than 250 articles on translational and clinical research.