Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.

List of Contents

Molecular Mechanisms of Corepressor Function
Role of Histone Deacetylase Complexes in the Regulation of Chromatin Metabolism
Corepressor Proteins and Control of Transcription in Yeast
Corepressor Proteins in Drosophila Development
Corepressors and Nuclear Hormone Receptor Function
Regulation of SMRT and N-CoR Corepressor Function
Corepressors and Retinoblastoma Protein Function
Smad Transcriptional Corepressors in TGF? Family Signaling
Role of Nuclear Receptor Corepressors in Leukemogenesis.