The aim of this volume is to give up-to-date information on animal models generated by transgenic or gene targeting techniques. Naturally, the focus is on the mouse system. Each chapter has been written by leading experts in the field and gives an overview on existing animal models. This is facilitated by tables, which list the most important genetically engineered animal models and their phenotypes. This book aims at  illustrating the impact of transgenic animal models in the field of Experimental Pharmacology and Toxicology, which includes their role in the understanding of basic cellular mechanisms, the evaluation of potential drug targets or the testing for drug effects.

 

1. Transgenic Techniques

Inducible Transgene Systems
2. Molecular Systems
Adrenergic System
Muscarinic Acetylcholine Receptor Knockout Mice
Mouse Models of NO/ Natriuretic Peptide/ cGMP Kinase Signaling
Transgenic Models for the Study of Protein Kinase A-regulated Signal Transduction
G-Protein-Mediated Signalling Pathways
Analysis of Integrin Function by Gene Targeting in Mice
3. Nervous System
Transgenic Mouse Models in the Analysis of Neurotransmitter Release Mechanism
Analysis of GABA Receptor Assembly and Function in targeted mutant mice
Neurotrophic Factors
Genetic Analysis of the Endogenous Opioid System
4. Cardiovascular System
Transgenic Mouse Models of Cardiovascular Function and Disease
Renin-Angiontensin-System/Blood Pressure Control
Lipoprotein Transport
5. Immunology/Hematology/Inflammation
Transgenic Animals of Enzymes and Receptors in Prostanoid Synthesis and Actions; Phenotypes and Implications in Drug Development
Coagulation and Fibrinolysis in Genetically Modified Mice
Transgenic Animals in Primary Hemostasis and Thrombosis
Chemokine Receptors
6. Endocrinology
Steroid Receptors
Reproductive System
Understanding Molecular Mechanism of Toxicity and Carcinogenicity Using Gene Knockout and Transgenic Mouse Models.