Most diseases are multifactoral. Transgenic technology permits gene(s) of interest to be expressed in a small manipulatable laboratory animal model. By this process, murine models of human infections can be developed and studied; effects of cytokines in vivo, focally expressed in unique cells can be established and manipulated, and a variety of autoimmune disorders, mimicking human disease can be constructed. In this volume, these approaches for study of human immunodeficiency virus, hepatitis virus, viruses causing tumors and chronic degenerative disorders are described. Also included are chapters of transgenic models of autoimmune disorders like diabetes, systemic lupus and ankylosing spondylitis.

Cytotoxic T Cell Effector and Memory Function in Viral Immunity

Transgenic Mouse Models of Experimental Autoimmune Encephalomyelitis
The Contribution of Insulitis to Diabetes Development in Tumor Necrosis Factor Transgenic Mice
Influence of T Lymphocytes and Major Histocompatibility Complex Class II Genes on Diabetes Susceptibility in the NOD Mouse
Virus-Induced Autoimmune Disease: Transgenic Approach to Mimic Insulin-Dependent Diabetes Mellitus and Multiple Sclerosis
Role of HLA-B27 in Spondyloarthropathies
The Influence of Cytokines on the Central Nervous System of Transgenic Mice
Mx Transgenic Mice - Animal Models of Health
Hepatitis B Virus Transgenic Mice: Models of Viral Immunobiology and Pathogenesis
Transgenic Models of HTLV-I Mediated Disease and Latency
Transgenic Models of Human Immunodeficiency Virus Type-1
Transgenic Models in the Study of AIDS Dementia Complex
Regulation of Expression and Pathogenic Potential of Human Foamy Virus In Vitro and in Transgenic Mice
Transgenetics of Prion Diseases
Poliovirus Biology and Pathogenesis
Safety Requirements for Maintenance and Distribution of Transgenic Mice Susceptible to Human Viruses: The Example of Poliovirus-Susceptible Transgenic Mice.