This supplement to Transplant International contains the Proceedings of the successful 5th Congress of the European Society for Organ Transplantation held in Maastricht from 7-10 October 1991. Of 827 abstracts submitted to the congress, 548 were selected by the Scien tific Committee for either oral or poster presentation. Of these 548 presenta tions, the guest editors selected 212 full papers for publication in this book. Two aspects are important where proceedings are concerned-the quality of the papers and the speed of publication. I thank our authors and guest editors, whose combined expertise has given us a guarantee of quality. I also thank our editorial and production teams for their tremendous efforts to hasten editing, proofreading, printing, and publication. In particular, I would like to express my gratitude to Maurits Booster, M.D., and Sylvia van Roosmalen for their assist ance and support in seeing this supplement through to completion. As a concession to time, we have waived some of our stringent rules of style and limited our correspondence with authors by, for example, page proofs being reviewed and corrected in house only. This enables us to publish two months earlier but has the disadvantage that, given the allotted time, we have not been able to ensure that each and every article has an abstract, nor that every "i" has been dotted in the reference lists or in the addresses/institute affiliations of all the authors.

Kidney

CSA/AZA, in the absence of prednisone, improves linear growth in renal transplanted children
Late histopathological findings in renal allografts with four immunosuppressive regimens
Flow cytometry evaluation of urinary sediment in renal transplantation
Early diagnosis of kidney transplant rejection and cyclosporine nephrotoxicity by urine cytology
Haemodynamic changes in human kidney allografts following administration of nifedipine: assessment with doppler spectrum analysis
Cyclosporine renal cortical vasoconstriction measured by colour doppler imaging in kidney transplantation
Monoclonal immunoglobulins in patients with renal transplants: characterization, evolution and risk factors
Cytomegalovirus (CMV) excretion as a factor in the severity of CMV disease in kidney and simultaneous kidney and pancreas transplantation
Prophylaxis of CMV disease by ganciclovir (DHPG) in seronegative recipients of renal allograft from seropositive donors
Renal retransplantation in patients with HLA-antibodies
Bilateral nephrectomy of the native kidneys reduces the incidence of arterial hypertension and erythrocytosis in kidney graft recipients treated with cyclosporine
A logical basis for age matching in organ transplantation: studies of recipient renal function in relation to donor age
Multicentre trial of ABO-incompatible kidney transplantation
Should hepatitits-C virus antibody-positive donors be excluded from kidney donation?
Cadaveric kidney donation beyond the age of 60 years - a comparative analysis of 1180 grafts from different donor age groups
Antibodies against hepatitis C virus among renal transplant patients in Greece
Value of panel reactive antibodies (PRA) as a guide to the treatment of hyperimmunized patients in renal transplantation
Cyclosporin A (CsA) and azathioprine (AZA) combination in renal allografts with CsA nephrotoxicity
Verapamil (VP) improves the outcome after renal transplantation (CRT)
DTPA renal scan assessment of renal allograft dysfunction in rats
Renal retransplantation in Switzerland: poor HLA matching of first and subsequent allografts does not appear to affect overal graft survival
Renal funtional reserve in kidney transplant recipients
Nifedipine improves immediate, and 6-and 12-month graft function in cyclosporin A(CyA) treated renal allograft recipients
Post-transplant haemoglobin levels and host kidney status
Effect of ATG prophylaxis in sensitized and non-sensitized kidney graft recipients
Ocular findings in patients with successful renal transplantation
Influence of cyclosporin A (CyA) on renal handling of urate
Erythrocytosis in renal allograft recipients. Benefit of staggered venous erythropoietin measurements
In vitro FK506 kidney tubular cell toxicity
FK506 mechanism of nephrotoxicity: stimulatory effect on endothelin secretion by cultured kidney cells
Early kidney transplantation may prevent aluminium-related bone disease
Effect of prostaglandin E1 on graft function of kidneys from living related donors
Renal transplantation in r-HuEPO-treated patients
Long-term beneficial effects of azathioprine addition to ongoing cyclosporine-prednisone protocol in renal transplantation
Protective effect of vasodilators in donors requiring pressor support
The use of OKT3 in steroid-resistant rejections following cadaveric kidney transplantation
Aging on the waiting list: should it be a further criterion for cadaver kidney allocation?
Risk factors for development of panel reactive antibodies and their impact on kidney transplantation outcome
Early or delayed onset of cyclosporine by sequential immunosuppression?
Application of flow cytometry in clinical renal transplantation
The course of HIV disease in renal allograft recipients
The Japanese Interferon Study Group (JISG) has established the efficacy of human interferon-p for serious CMV pneumonitis in kidney recipients
Factors affecting the long-term outcome following non-living kidney transplantation
Is repeated mismatching at regrafting deleterious?
Detrimental role of donor-recipient HLA-DQ5 and -DQ6 disparities on cadaver kidney graft survival
CMV prophylaxis after renal transplantation with immunoglobulin or CMV-hyperimmunoglobulin - a prospective clinical trial
Length of time on dialysis prior to renal transplantation is a critical factor affecting patient survival after allografting
Donor conditions and graft survival-a retrospective study
Clinical factors which influence the long-term survival of kidney allografts donated from haploidentical donors
Glomerular hyperfiltration after unilateral nephrectomy in living kidney donors
Liver
The bile acid independent flow is reduced in the transplanted liver
Quadruple immunosuppression including a new IL-2-receptor antibody and the incidence of infections after liver transplantation
Should retransplantation still be considered for primary non-function after liver transplantation?
Increased fibrinolysis in orthotopic but not in heterotopic liver transplantation: the role of the anhepatic phase
A Pugh score of 8 adequately selects patients with parenchymal cirrhosis for liver transplantation
Seroprevalence and outcome of hepatitis C in liver transplantation
Somatomedin C (IGF I) plasma levels after orthotopic liver transplantation (OLT) in end-stage cirrhotic patients
Adjuvant treatment with ursodeoxycholic acid reduces acute rejection after liver transplantation
Cholestasis and kidney dysfunction in liver transplant patients reduces cyclosporine metabolite excretion
Choledochoenterostomy with an anti-reflux mechanism
Liver transplantation in hepatocellular carcinoma
Technique of arterial anastomosis in liver transplantation, surgical management in routine situations and anatomical variations
Biliary neopterin for differentiation between liver allograft rejection and viral graft infection
Total hepatectomy and liver transplant for hepatocellular adenomatosis and focal nodular hyperplasia
Liver transplantation for fulminant liverfailure in children
The impact of the different severe infections on the outcome of liver transplantation. Astudy of 150 patients
Hepatic support by hepatocyte transplantation in congenitally metabolic diseased rats
Blood transfusion in orthotopic liver transplantation: six-year experience
Liver transplantation for small HCC in cirrhosis
Heart, Lung, Heart-Lung
Results of acute heart retransplantation in Eurotransplant
Right ventricular failure after heart transplantation: relationship with preoperative haemodynamic parameters
Preoperative prostaglandin E1 treatment to prevent right ventricular failure after orthotopic heart transplantation
Phenotype of endomyocardial biopsy-derived T-lymphocyte cultures and chronic rejection after heart transplantation
The clinical value of ultrasonic tissue characterization in the management of heart transplant patients
Coronary flow reserve is impaired early after cardiac transplantation
Determinants of graft arteriosclerosis after heart transplantation
Role of CMV pneumonia in the development of obliterative bronchiolitis in heart-lung and double-lung transplant recipients
The use of allopurinol in the inhibition of obliterative bronchiolitis of the transplanted lung
Evaluation of the International Society for Heart Transplantation (ISHT) grading of pulmonary rejection in 100 consecutive biopsies
Coronary flow reserve and coronary occlusive disease
Tricuspid valve insufficiency as a complication of endomyocardial biopsy
Occurrence of lymphoproliferative disorder after heart transplantation is related to the total immunosuppressive load
Pancreas, Islets, Small Bowel
Perfusion imaging of pancreas allografts using technetium-99m hexamethyl propylene amine oxime
Prospective analysis of pancreatic grafts with duplex-Doppler ultrasound: value of resistive index in the diagnosis of rejection
Reperfusion injury of pancreas allografts: relation to islet cell function
Isolation of pig pancreatic islets by a new method with hydraulic shaking: preliminary report
The use of FK506 and RS61443 for reversal of small-bowel rejection
Graft Monitoring
Monitoring of cardiac graft recipients: comparison of in vivo activated, committed T lymphocytes in peripheral blood and in the graft
Intercellular adhesion molecule 1 (ICAM-1) induction on hepatocytes is an early marker of acute liver allograft rejection
Lung transplantation: pulmonary cell lysis mediated by alveolar mononuclear cells
Nonspecific hemolytic effector of activated macrophages as activation marker of allograft rejection
Relation of suppressor activity to lymphocyte subsets, in vitro IL-2R expression, and biopsy results in cardiac transplant patients
?2-Microglobulinuria as an early sign of cytomegalovirus infection following renal transplantation
Xenografting
Perfusion of rabbit hearts with human blood results in immediate graft thrombosis, a temporally distinct component of hyperacute rejection
Allogeneic heart transplantation following xenogeneic bridging
Activation of the alternative pathway of complement is an important component of hyperacute rejection of rabbit hearts by human blood
Inhibition of rejection of hamster-to-rat heart xenografts
Perfusion of rabbit hearts with pig blood results in complement mediated hyperacute xenograft rejection
Antibody binding to endothelial and epithelial antigens triggers pig-to-rabbit xenograft rejection and its absence results in atypical complement deposition
Preservation
The influence of an improved preservation solution on prognostic factors for graft survival in pediatric liver transplantation
Multivisceral cluster transplantation in the rat
Reperfusion rather than storage injury predominates following long-term (48 h) cold storage of grafts in UW solution: studies with Carolina Rinse in transplanted rat liver
Prolonged rat pancreas preservation using a solution with the combination of histidine and lactobionate
The impact of liver preservation in HTK and UW solution on microcirculation after liver transplantation
Myocardial preservation with the UW solution. First European results in clinical heart transplantation
Protection by pentoxifylline against graft failure from storage injury after orthotopic rat livertransplantation with arterialization
Pulmonary mechanics after cardio-pulmonary transplantation, an experimental study
Simplified microvascular suture techniques for rat liver transplantation as a microsurgical model with arterial blood supply
The second generation of Carolina Rinse, solution II, improves graft survival following orthotopic liver transplantation in the rat by preventing reperfusion injury
Efficacy of PGI2 analog in preventing ischemia reperfusion damage of liver grafts from living donors
Heart and lung preservation using a new solution; UCLA Formula
Antagonisation of platelet activating factor- a new therapeutic concept for improvement of organ quality in lung preservation
Usefulness of 31P-MRS as a method of evaluating the viability of preserved and transplanted rat liver
Predictive value of liver tissue flow in assessment of the viability of liver grafts after extended preservation in pigs
Successful 96-hour preservation of the canine pancreas
The mechanism of action of the two-layer (Euro-Collins' solution/perfluorochemical) cold storage method in canine pancreas preservation
Improvement of liver preservation by the calcium channel blocker nisoldipine. An experimental study applying intravital microscopy to transplanted rat livers
The calcium channel blocker nisoldipine minimizes the release of tumor necrosis factor and interleukin-6 following rat livertransplantation
Comparison of HTK- and UW-solution for liver preservation tested in an orthotopic livertransplantation model in the pig
Acomparison of histadine lactobionate solution with University of Wisconsin solution for rat liver and heart preservation
The significant role of membrane stabilization in hypothermic cardioplegic cardiac preservation in a canine experimental model
Kupffer cell and hepatocyte function in rat transplanted liver
A newly developed hydroxyI radical scavenger, EPC-K1 can improve the survival of swine warm ischemia-damaged transplanted liver grafts
Kidney procurement from non-heartbeating donors: transplantation results
Apreliminary report of the HTK randomized multicenter study comparing kidney graft preservation with HTK and EuroCollins solutions
The relationship between cause of death of the kidney donor and the presence of ischemic lesions in the kidney
Immunosuppression
High or low dose steroid therapy for acute renal transplant rejection after prophylactic OKT3 treatment: a prospective randomized study
The risk of infection following OKT3 and antilymphocyte globulin treatment for renal transplant rejection: results of a single center prospectively randomized trial
Prophylactic use of the IL-2 receptor-specific monoclonal antibody LO-Tact-1 with cyclosporin A and steroids in renal transplantation
RS-61443: successful rescue therapy in refractory renal rejection
Lymphoproliferative disorders developing after transplantation and their relation to simian T-cell leukemia virus infection
Toxicology of FK506 in the cynomolgus monkey: a clinical, biochemical, and histopathological study
CD4-specific monoclonal antibody can prolong cardiac allograft survival without T-cell depletion
Prolongation of heart allograft survival in rats by interferon-specific antibodies and low dose cyclosporin A
Effect of LS-2616 on the graft protection achieved by cyclosporin A, prednisolone, and 15-deoxyspergualin in heart-transplanted rats
A randomized pilot study of cyclosporin G in renal transplantation
Long-term immunosuppression after liver transplantation: are steroids necessary?
Dosage of OKT3 independent of body weight: a mistake?
Polyclonal versus monoclonal rejection prophylaxis after heart transplantation: a randomised study
Pregnancy in kidney recipients under cyclosporine
Low-dose combination therapy of DUP-785 and RS-61443 prolongs cardiac allograft survival in rats
Immunomodulation of dog islets using a cocktail of monoclonal antibodies
Prolongation of murine thyroid allografts by interleukin 2 (DAB486)-toxin and RS-61443
The effects of nifedipine on cyclosporine nephrotoxicity in rats
Cyclosporine-induced insulin release in rats is related to an increase in plasma lipid levels
Cellular mechanisms: Induction of heart allograft survival in rats by 15-deoxyspergualin
Control of humoral and cellular immunity-mediated accelerated heart allograft rejection in sensitized rats by low dose FK506 and splenectomy
Prevention of lethal graft-versus-host disease by monoclonal antibody treatment in vivo
Abdominal organ cluster transplantation in pigs and FK506
Influence of hepatic dysfunction on cyclosporine metabolism in the pig
FK506 and rapamycin: differential sensitivity of human, baboon, cynomolgus monkey dog and pig lymphocytes
Ex vivo perfusion of canine pancreaticoduodenal allografts using class-II-specific monoclonal antibody delays the onset of acute rejection
New immunosuppression with monoclonal antibody to intracellular adhesion molecule 1 (ICAM-1) in rat organ transplantation
Japanese study of kidney transplantation: 1. Results of early phase II study
Subclinical impairment of distal renal acidification induced by low-dose cyclosporin Atherapy
Cyclosporin A has no impact on alterations of the lipid profile after renal transplantation
Decrease of erythrocyte deformability in cyclosporine-treated renal transplant patients: correction with fish oil as well as corn oil
Adjuvant treatment with ursodeoxycholic acid prevents acute rejection in rats receiving heart allografts
RS-61443 reverses acute renal allograft rejection in dogs
Gangliosides potentiate the immunosuppressive effects of cyclosporin A in rat skin allografts
Rescue therapy for acute rejection using 15-deoxyspergualin (DSG) in combination with superoxide dismutase (SOD) on cardiac allografts in rats
Japanese study of FK506 on kidney transplantation: 2. Follow-up study of FK 506-treated patients
Insensitivity to cyclosporine may explain the HLA-DRw6 recipient effect
An immunoglobulin-specific autoantibody occurring during alloimmunization suppresses the antibody response
Prevention of cardiac allograft rejection by FK506 and rapamycin: assessment by histology and nuclear magnetic resonance
New morphological changes induced by FK506 in a short period in the rat kidney and the effect of superoxide dismutase and OKY-046 on THEM: the relationship of FK506 nephrotoxicity to lipid peroxidation and change in production of thromboxane A2 in the kidney
Immunology
Is tolerance a prospective for clinical research?
Will chronic rejection ever respond to treatment?
DNA typing: an important step forward?
The "rejection reaction" is not confined solely to the allograft
Chronic rejection of rat aortic allografts: effect of inhibition of the thromboxane cascade
Factors involved in peripheral T cell tolerance: the extent of clonal deletion or clonal anergy depends on the age of the tolerized lymphocytes
Alio and auto crossmatches after transplantation
Remarkable correlation between increased HLA-DQ antigen positive monocytes and prognosis of renal transplantation
The influence of DR match of blood donor and recipient on the formation of T- and B-cell antibodies and on renal allograft outcome
Success rate and impact of HLA matching on kidney graft survival in highly immunized recipients
Flow cytometric crossmatching and outcome one year after renal transplantation
Clinical relevance of soluble HLA and interaction of papain derived class I molecules with alloreactive CTL
Lack of correlation between IgG T-lymphocyte flow cytometric crossmatches with primary renal allograft outcome
Detection of latent human cytomegalovirus in organ tissue and the correlation with serological status
Reactivity of renal transplant sera against a 17 kD mononuclear cell antigen
Strength of HLA-A, HLA-B, and HLA-DR mismatches in relation to short- and long-term kidney graft survival
Pretransplant serum lgG-anti-F(abé)2 g activity and kidney graft outcome: comparison of results obtained at two centers
The impact of ischemic lesions in the donor kidney donor age, recipient age and HLA(A, B, C, DR, DQ) matching on clinical course after kidney grafting
Non specific increased expression of class I major histocompatibility complex (MHC) antigens on rat liver grafts
Intraoperative cytokines production during orthotopic liver transplantation
Studies on the participation of different T cell subsets in rat liver allograft rejection
Chronic renal allograft rejection: the significance of non-MHC alloantigens
Lysis of heart endothelial cells from donor origin by cardiac graft infiltrating cells
Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement
TNF staining of graft biopsy in renal transplantation
Analysis of suppressor T cells induced by donor-specific transfusion (DST): establishment of a human T cell hybridoma producing an antigen-nonspecific suppressor factor
Role of leukotrienes B4 and C4 in liver allograft rejection
Suppression of human lymphocyte proliferation and cytotoxic T lymphocyte generation by a soluble factor derived from K562 cells
FK506 ameliorates normothermic liver ischemia in rats by suppressing production of tumor necrosis factor
Donor directed cytotoxicity of cardiac graft infiltrating cells during cytomegalovirus infection
The influence of HLA-mismatches on phenotypic and functional characteristics of graft infiltrating lymphocytes after heart transplantation
Kidney transplant monitoring by anti donor specific antibodies
Cytokines in lethal graft-versus-host disease
Absence of correlation between graft-versus-host associated immunosuppression and cytotoxic T cell activity in response to major histocompatibility antigens
Rejection prophylaxis with interleukin-2 receptor antibody BT 563: mechanisms of action on human cells
Hyaluronic acid accumulation; the mechanism behind graft rejection edema
Expression of activation markers, HLA class II and IL-2R in acute vascular rejection of human renal allografts
Cytokines
T-cell receptor Vb gene usage by lymphocytes infiltrating human renal allografts
Effects of interleukin 2 receptor b chain (P75)-specific monoclonal antibody on the generation of cytotoxic T lymphocytes and suppressor T cells in mixid lymphocyte culture
Quality of Life
Quality of life before and after liver transplantation: experiences with 7 patients with primary biliary cirrhosis in a 2-year follow-up
Effect of kidney transplantation on quality of life measures
Cognitive and behavioural status of paediatric patients 1 year after cardiac or cardiopulmonary transplantation
The Donor Problem
Perioperative hemodynamic heterogeneity of brain dead organ donors
A reliable and safe way of shortening cadaver kidney ischemia time: prenephrectomy tissue typing using donor lymph node cells
Assessment of costs to donor hospitals for organ transplantation
Impact of donor age on living related donor kidney transplantation.