Some three decades after bone marrow transplantation was introduced in the field of hematology and oncology, transplantation today continues to rapidly grow and expand into a variety of new modalities. Peripheral blood has been established as an effective source of autologous progenitor cells. Furthermore, the graft-versus-leukemia effect has resulted in novel strategies of adoptive immunotherapy for cancer. Finally, approaches to gene transfer and therapy are utilizing transplantation methodologies and can augment their effects. Current results, new developments and perspectives are presented in this volume. Conventional and innovative experimental approaches, the past and the future of bone marrow transplantation are reviewed and discussed by leading representatives.

Transplantation: State of the Art

Hematopoietic Cell Transplantation: The First 50 Years and a Glimpse of the Future
Current Status of Blood and Marrow Transplantation
Stem Cells and Growth Factors
Normal and Leukemic Human Stem Cells
Thrombopoietic Growth Factors - Managing Thrombocytopenia
Erythropoietin Use in Therapy of Anemia Associated with Bone Marrow Transplantation in Children
Autotransplantations of Peripheral Blood Progenitor Cells, Collected After Mobilization by Single-Dose Betaleukin (rh-IL-1b)
Stem Cells: Donors and Sources
Allogeneic Cord Blood Hematopoietic Stem Cell Transplants in Malignancies
Future Source of Allogeneic Stem Cells: Bone Marrow or Peripheral Blood?
Marrow Unrelated Donor Transplantation: European Experience
Immune Effects and Cellular Immune Therapy
New Strategies for Hematopoietic Stem Cell Transplantation
Nonmyeloablative Allogeneic Stem Cell Transplantation: Towards Improving Efficacy of Immunotherapy Instead of Myeloablative Chemoradiotherapy
Autologous Peripheral Blood Stem Cell Transplantation in Childhood Metastatic Osteosarcoma
Mycophenolate Mofetil for the Treatment of Acute and Chronic GVHD in Bone Marrow Transplant Patients
Peripheral Blood and Bone Marrow Derived Dendritic Cells in Acute Myelogenous Leukemia
Minimal Residual Disease: Detection and Treatment
Biologic Effects of TBI
Autologous Stem Cell Transplantation and Cell Therapy for Acute Leukemia
Positive Selection of Hematopoietic Progenitor Cells for Autologous and Allogeneic Transplantation in Pediatric Patients with Solid Tumors and Leukemia
Simultaneous Double-Purging of Breast Cancer Cells from Leukapheresis Products by Imunomagnetic CD34+ Cell Enrichment and Tumor Cell Depletion
Immunomagnetic Purging of Marrowand Peripheral Blood Progenitors for Autografting in Patients with Lymphoproliferative Disorders - Selection Efficacy and Engraftment
Establishment of an NOD/SCID Mouse Model for Ewing Tumors: A Potential Preclinical Model to Test Novel Purging Strategies
Molecular Genetic Detection of Minimal Metastatic and Residual Disease in Ewing's Tumors
Molecular Monitoring of Treatment Efficacy after Hematopoietic Stem Cell Transplantation in Chronic Myeloid Leukemia
Detection of Residual Tumor Cells by RT-PCR for Tyrosine Hydroxylase mRNA
Autologous Transplantation in Leukemias, Lymphomas, and Solid Tumors
Autograft Followed by Allograft Without Myeloablative Conditioning Regimen: A New Approach for Resistant Hematologic Neoplasia and Breast Cancer
Possible Prognostic Benefit from ABMT in First Remission Adult Acute Lymphoblastic Leukemia
Updated Results of an Age-Adapted Consolidation Strategy with ABMT ( 50 Years) in Adult Acute Myeloid Leukemia
Mobilization of Peripheral Blood Stem Cells after Intensive Induction and Consolidation Therapy in Adult Patients with De Novo Acute Myeloid Leukemia
Autologous Stem Cell Transplantation in Acute Promyelocytic Leukemia Patients Achieving a Second Complete Remission
Autologous Hematopoietic Cell Transplantation for Lymphoid Malignancies
Dexa-BEAM with High-Dose Cytarabine and Autologous Bone Marrow Transplantation are Highly Effective in Heavily Pretreated Poor-Prognosis Lymphoma Patients
Delayed Granulocyte Recovery and Suppressed Growth of Grafted CFU-GM If Allogeneic Marrow Cells are Transplanted 48 h After the Completion of High-Dose Busulfan and Cyclophosphamide (BuCy2) Therapy
High-Dose Chemotherapy for Primary Metastatic or Relapsed Ewing Tumours: Outcome of 120 (EI) CESS Patients
AutologousPeripheral Blood Stem Cell Transplantation in Childhood Metastatic Osteosarcoma
Approaches to Gene Therapy
Retroviral Transfer and Expression of Drug Resistance Genes in Hematopoietic Cells
Gene Therapy with Cord Blood Hematopoietic Stem Cells for Adenosine Deaminase Deficiency: An Update
Adenovirus Mediated P53 (Adp53) Gene Transfer
Pharmacological Gene Therapy for Experimental Brain Tumors
Transgenic Expression of IL-2 in Peripheral Neuroectodermal Malignancies of Childhood: In Vitro and In Vivo Effects on Lymphocyte Activation and Tumor Lysis
Suicide Gene Transduced T-Cells for the Regulation of the Graft-Versus-Leukemia Effect
Defining Current Strategies for Future Human Trials in Gene Therapy.