The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy.  The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities.
Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.

Historical Perspective of Trauma Induced Coagulopathy

Epidemiology of Hemorrhage-related Mortality
Cell-Mediated Hemostasis
Thrombin-Antithrombin System
Physiology of Hemostasis: Plasmin-antiplasmin system
Thrombin Formation
Platelets
Fibrinogen
Defining and Assessing the Endotheliopathy of Trauma and its Implications on Trauma Induced Coagulopathy and Trauma Related Outcomes
Protein C
Fibrinolysis Dysregulation following Trauma
Complement System
Neutrophils, Inflammation and Innate Immunity in Trauma-Induced Coagulopathy
Disseminated Intravascular Coagulation
Grading Clinical Coagulopathy and Predicting Massive Transfusion
Prothrombin and Partial Thromboplastin Time
Fibrinogen Assays
Rotational Thromboelastometry (ROTEM®)
Thromboelastography (TEG® 5000 and TEG® 6s Hemostasis Analyzers with TEG Manager® Software)
Red Blood Cell Transfusions
Plasma Transfusion
Cryoprecipitate/ Fibrinogen Concentrate Transfusions
Platelet Transfusion
Whole Blood for the Resuscitation of Massively Bleeding Civilian Patients
Adjunct Factor Replacement
Anti-fibrinolytics
Ratio Driven Massive Transfusion Protocols
Goal-Directed Massive Transfusion Management
Pre-Hospital Resuscitation
Venous Thromboembolism after Trauma
Fibrinolysis Shutdown and Venous Thromboembolism
Congenital and Acquired Hypercoagulable States
Pediatrics
Traumatic Brain Injury-Induced Coagulopathy
Blunt Solid Organ Injury: A Call for Timely Chemoprophylaxis in the Setting of Early Hypercoagulability
Pregnancy
Liver Failure
Pulmonary Coagulation in the Pathogenesis of Trauma-Associated Acute Respiratory Distress Syndrome
Management of Chronically Anticoagulated Patients
Randomized Controlled Trials: Informing Clinical Practice for Traumatically Injured Patients
The Quantra® System and SEER Sonorheometry
Dried Plasma for Trauma Resuscitation
Synthetic Blood Substitutes
Flow-Based Coagulation and Fibrinolysis Assays
Animal Models ofCoagulopathy
Applications of Viscoelastic Hemostatic Assays at the Site of Care: Considerations and Implications.