This book contains the papers delivered at the Symposium on "Medical Treatment of Brain Ede ma" at the Seventh International Congress ofNeu rological Surgery, held in Munich in 1981. The aim of each speaker was to give a short review of current knowledge in his or her field. In addition, most of the authors presented their own data. The symposium . was divided into two parts. The experimental part focused on pathophysiological and biochemical findings, while the clinical part dealt with therapy for brain edema, with particular emphasis on steroids. We wish to acknowledge the technical support of Springer-Verlag, Merck Company, Darmstadt and the help of Miss Scholz, Secretary of the Depart ment of Neurology at the University of Heidel berg. Heidelberg/Berlin A. Hartmann M. Brock v Contents K. -A. Hossmann Pathophysiology of Va so genic and Cytotoxic Brain Edema . . . . . . . . . . . . . . . . . . . A. Marrnarou, K. Tanaka, and K. Shulmann The Brain Response to Infusion Edema: Dynamics of Fluid Resolution . . . . . . . . . . 11 M. D. O'Brien 19 Ischemic Cerebral Edema A. Baethmann, W Oettinger, K. Moritake, L. Chaussy, andF. Jesch Metabolic Effects of Corticosteroids in Central Nervous Tissue . . . . . . . . . . . . . 24 K. Maier-Hauff, O. Kempski, A. Unterberg, U. Gross, M. Lange, L. Schurer, and A. Baethmann The Kallikrein-Kinin-System as Mediator in Cerebral Edema, Recent Progress . . . . . . . . . . . . . 31 S. F. Berndt 36 Symptoms of Cerebral Edema W R. Lanksch The Diagnosis of Brain Edema by Computed Tomography . . . . . . . . . . . . . . 43 H. J. Klein and K. Schmidt Hyperosmolar Solutions and Diuretics in the Treatment of Brain Edema . . . . . . . .

Pathophysiology of Vasogenic and Cytotoxic Brain Edema

The Brain Response to Infusion Edema: Dynamics of Fluid Resolution
Ischemic Cerebral Edema
Metabolic Effects of Corticosteroids in Central Nervous Tissue
The Kallikrein-Kinin-System as Mediator in Cerebral Edema, Recent Progress
Symptoms of Cerebral Edema
The Diagnosis of Brain Edema by Computed Tomography
Hyperosmolar Solutions and Diuretics in the Treatment of Brain Edema
The Effect of High Doses of Steroids on Traumatic Brain Edema
The Effect of Dexamethasone on the Level of Adrenaline and Noradrenaline in Patients with Multiple Injuries
The Influence of Dexamethasone on the Midbrain Syndrome After Severe Head Injury
Clinical Use of Steroids in Cerebral Abscesses
The Effect of High Doses of Dexamethasone on Cerebral Blood Flow in Patients with Cerebral Tumors
Use of Dexamethasone and Frusemide in Brain Edema Resulting from Brain Tumors
Effect of Dexamethasone on Regional Cerebral Blood Flow in Ischemic Cerebral Infarction
Is Brain Edema Amenable to Treatment?.