These are exciting days in biology; chromosome such functional attributes of chromosomes as research is no exception. Twenty years ago when replication, dosage compensation and cellular Caspersson and coworkers showed that meta response to DNA lesions. It is only recently that a phase chromosomes are structurally not homo molecular view of the meiotic cell division is geneous through their length, a new world was beginning to emerge: chapter ten refers to human in the offing. Application of various molecular meiosis and the next to molecular events in techniques in chromosome research has subse meiotic prophase in the baker's yeast. Another quently narrowed down the gap between the chapter is on aneuploidy in man and the Djungarian levels of microscopic and molecular understand hamster. The role of chromosome rearrange ing of chromosome organization. While complex ments and oncogenes in malignancy and the ities of older questions of chromosome/ parallelism between the neoplastic and phy chromatin organization are being understood, logenetic chromosomal alterations are discussed newer dimensions and perspectives have been in the next two chapters. Recent introduction of gained with respect to their structure and func potentially useful methods of chromosome isola tions. Even more, novel chromosome techniques tion by flow cytometry, and mapping of structural have become an integral component of clinical ly and functionally distinct domains on metaphase and molecular genetic methodologies.

1 DNA Organization in the Interphase Nucleus and Metaphase Chromosome

2 On Interspersed Repetitive DNA Sequences in Animals
3 Chromatin Structure and Gene Expression in Eukaryotes
4 Contents of G- and R-bands Defy Contemporary Paradigms
5 Examination of the Structure and Function of the Mammalian Centromere
6 Comparative Aspects of Chromosome Replication in Drosophila and Mammals
7 Dosage Compensation in Drosophila and Mammals: A Review of the Past and Speculation for the Future
8 Steroid Sulphatase Inactivation Patterns and X-chromosome Inactivation
9 Chromosomal Aberrations from Radiation-induced DNA Lesions
10 Current and Future Trends in Human Meiotic Research
11 Meiotic Developmental Features Relevant to Prophase Specific Chromosomal Characteristics in Saccharomyces cerevisiae
12 Aneuploidy in Man and Mechanisms of Nondisjunction Inferred from Studying Djungarian Hamster Oocytes
13 Chromosome Alterations and Oncogenes in Human Neoplasia
14 Chromosome Alterations in Speciation and Neoplastic Transformation: A Parallelism
15 Flow-cytometry: A Tool in Cytogenetics
16 Restriction Enzyme Banding of Metaphase Chromosomes
17 DNase I-nick Translation Technique: A Cytogenetic Approach to Map Active Chromatin
18 Chromosomal Speciation: Constitutive Heterochromatin and Evolutionary Differentiation of the Indian Pygmy Field-Mice
Author Index.