Type IV secretion systems (T4SSs) are highly versatile membrane-associated transporter machines used by Gram-negative and Gram-positive bacteria to deliver substrate molecules to a large variety of target cells. This volume summarizes our current knowledge of the large variety and structural diversity of T4SSs in pathogenic Escherichia, Agrobacterium, Legionella, Coxiella, Bartonella, Helicobacter, Enterococcus and other species. Divided into 13 chapters contributed by leading experts, it presents findings that significantly enhance our understanding of how various pathogens manipulate host cell functions to trigger bacterial uptake, promote intracellular growth, suppress defense mechanisms and of how bacteria spread antibiotic resistances, thus facilitating bacterial colonization and disease development. The book is an invaluable source of information for researchers and clinicians.

Biological diversity of prokaryotic type IV secretion systems

Evolution of type IV secretion systems and their substrates
Structural and molecular biology of type IV secretion systems
Relaxosome formation and transfer of broad-host range plasmids Gram-negative bacteria
Mechanisms of conjugative transfer by Gram-positive broad-host range plasmids
Social behavior and decision making in bacterial conjugation
Structure and chemical biology approaches to understand type IV secretion system function and inhibition
Type IV secretion systems: A pivotal tool to establish intracellular lifestyle by pathogens
Subversion of host target cells by the Legionella type IV secretion system
Role of multiple type IV secretion systems in Bartonella infections
Requirements for T4SS effector protein translocation and function by the Coxiella Dot/Icm system
Composition and function of the Helicobacter pylori cag type IV secretion system
Secretion of chromosomal DNA by the gonococcal type IV secretion system.