Vitamin E is a well described and established fat-soluble essential micronutrient and as such has to be provided to the human body on a regular basis in order to avoid deficiency and maintain a healthy status. This is well established and also reviewed in a number of publications. However, a huge body of evidence has accumulated over the last decade, or so, which provides new insights on the mode of action of vitamin E, and the biological role of the tocopherol isomers, and sheds new light on the role of vitamin E in human health. Both fundamental knowledge gain and new data on the role and challenges of vitamin E as an essential micronutrient, including emerging evidence on clinical benefits, will be addressed to put this essential micronutrient in the appropriate perspective.  
Given this level of new evidence which has emerged over the recent years, a book on vitamin E will put into perspective the concerns which have been raised on vitamin E and which resulted in a misinformation and confusion of the public regarding the importance of vitamin E for human health. This book will reemphasize that Vitamin E is clearly required for human health and its inadequacy leads to increased risk of a variety of diseases. In addition new data of non-communicable diseases (NCD) dependent on vitamin E status show that a lifetime of low intake increases risks of development, severity and complications of NCDs. This text will put the vitamin E case into an up-to-date, science based, applicable real-life perspective and offer pragmatic solutions for its safe and personalized use beyond the various methodological and statistical controversies. The purpose of this book is also to raise awareness not only in the nutrition and medical community, but also in the public media that there are a number of health conditions where an increased intake of vitamin E can be of potential importance. Further this review shouldalso stimulate funding organizations and agencies to increase their support for vitamin E research in order to facilitate the further exploration of the safe and efficacious use of this essential micronutrient.

Introduction

History of Vitamin E Research
Antioxidative Activity of Vitamin E
Bioavailability and Metabolism of Vitamin E
Occurrence and Bioactivities of Minor Vitamin E Derivatives
Bioactivity of Vitamin E Long-Chain Metabolites
Gene-regulatory Activity of Vitamin E
Metabolomic Approaches in Vitamin E Research
The Tocopherol Transfer Protein: Regulator of Vitamin E Status
The Role of Lipid Rafts in Mediating the Anticancer Effects of y-Tocotrienol
Interaction between Vitamin E and Polyunsaturated Fatty Acids
The Challenge of Defining Daily Intake Recommendations: Vitamin E and Polyunsaturated Fatty Acids
Vitamin E Intake and Serum Levels in the General Population: a Global Perspective
Vitamin E Serum Levels and the Challenge to Correct for Lipids: Accounting for the Usual Double Correction for Variance shared by Total Cholesterol and Fasting Triglycerides Reveals New Insights into the Association with the One Carbon Pathway
Stability of Vitamin E in Foods
Vitamin E and Mortality: A Critical Perspective of the Conflicting Meta-Analysis Outcomes
Vitamin E: Drug Interactions
Vitamin E: Interactions with Vitamin K and other Bioactive Compounds
Clinical Cardiovascular Disease Trials: The Vitamin E Case
Haptoglobin Genotype and a Promising Pharmacogenomic Approach to Prevent Diabetic Atherothrombosis with Vitamin E Supplementation
Vitamin E and Metabolic Syndrome
Vitamin E in nonalcoholic Fatty Liver Disease
The Role of Vitamin E in Aging and Alzheimer's Disease
The Impact of Vitamin E Isoforms on Asthma and Allergy
Vitamin E, Immune Function, and Protection Against Infection
Vitamin E and Air Pollution
The Role of Vitamin E in Pregnancy
Vitamin E and Health Care Costs: Models to Assess the Impact
Do Consumers Care about Micronutrients? A Perspective on the Possible Role of Vitamin E in the Dietary Choices of Consumers
Addressing Key Knowledge Gaps in Nutrition and the Impact of Funding Priorities in Human Nutrition.