The fourth, completely revised edition of this classic reference and textbook presents a cohesive and up-to-date exposition of the concepts, results, and problems underlying theory and practice in human and medical genetics. In the 10 years since the appearance of the third edition, many new insights have emerged for understanding the genetic basis of development and function in human health and disease. Human genetics, with its emphasis on molecular concepts and techniques, has become a key discipline in medicine and the biomedical sciences.

The fourth edition has been extensively expanded by new chapters on timely topics such as epigenetics, pharmacogenetics, gene therapy, cloning, and genetic epidemiology, and databases for basic and clinical genetics. In addition a multi/chapter section giving an overview on the main model organisms (mouse, dog, worm, fly, fish) used in human genetics research has been introduced.

This book will be of interest to human and medical geneticists, scientists in all biomedical sciences, physicians and epidemiologists, as well as to graduate and postgraduate students who desire to learn the fundamentals of this fascinating field.

History of Human Genetics*

Human Genome Sequence and Variation
Chromosomes
From Genes to Genomics to Proteomics
Formal Genetics of Humans: Modes of Inheritance*
Linkage Analysis for Monogenic Traits
Oligogenic Disease
Formal Genetics of Humans: Multifactorial Inheritance and Common Diseases
Lessons from the Genome-Wide Association Studies for Complex Multifactorial Disorders and Traits
Epigenetics
Human Gene Mutation: Mechanisms and Consequences
Human Hemoglobin
Human Genetics of Infectious Diseases
Gene Action: Developmental Genetics
Cancer Genetics
The Role of the Epigenome in Human Cancers
Population Genetic Principles and Human Populations
Consanguinity, Genetic Drift, and Genetic Diseases in Populations with Reduced Numbers of Founders
Human Evolution
Comparative Genomics
Genetics and Genomics of Human Population Structure
Genetic Epidemiology
Pharmacogenetics
Behavioral Genetics
The Genetics of Personality
Mental Retardation and Intellectual Disability
Genetic Factors in Alzheimer Disease and Dementia
Genetics of Autism
The Genetics of Alcoholism and Other Addictive Disorders
Behavioral Aspects of Chromosomal Variants
Geneties of Schizophrenia and Bipolar Affective Disorder
Model Organisms for Human Disorders
Mouse as a Model for Human Disease
Caenorhabditis elegans, A Simple Worm: Bridging the Gap Between Traditional and Systems-Level Biology
Drosophila as a Model for Human Disease
Human Genetics and the Canine System
Fish as a Model for Human Disease
Genetic Counseling and Prenatal Diagnosis
Gene Therapy
Cloning in Research and Treatment of Human Genetic Disease
Genetic Medicine and Global Health
Genetic Databases
Databases and Genome Browsers
Ensembl Genome Browser
Databases in Human and Medical Genetics.