This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Preface

Part I
Evolution of voltage-gated sodium channels
1. Evolutionary History of Voltage-Gated Sodium Channels
2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function
3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective
4. The Cardiac Sodium Channel and Its Protein Partners
5. : Posttranslational Modification of Sodium Channels
6. Sodium Channel Trafficking
7. pH Modulation of Voltage-Gated Sodium Channels
8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C.- Part III. Drugs and toxins interactions with sodium channels.- 9. Toxins That Affect Voltage-Gated Sodium Channels
10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels
11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels
12. Structural Models of Ligand-Bound Sodium Channels
13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7
Part IV. Pathophysiology of sodium channels.- 14. Sodium Channelopathies of Skeletal Muscle
15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction
16. Translational Model Systems for ComplexSodium Channel Pathophysiology in Pain
17. Gating Pore Currents in Sodium Channels
18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells
19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases.