This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. 

The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 - ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.

Overview

Foreign Compounds: Foods, Drugs and Other Chemicals
Absorption, Metabolism and Excretion of Foreign Compounds
Metabolism of Foreign Compounds
Bioactivation Metabolism: Activation Enzymes
Functionalization Reactions Catalyzed by Activation Enzymes
Detoxifying Metabolism: Detoxification Enzymes
Conjugation Reactions Catalyzed by Detoxification Enzymes
Reactive Intermediates Generated from Bioactivation
Electrophilic Nature of Metabolic Reactive Intermediates
Oxidative Stress Mediated by Reactive Intermediates
Xenobiotics Bioactivation - Mediated Cellular Damages
Nrf2 - ARE Pathway: Defense Against Oxidative Stress
Genetic Variations and Polymorphisms of Metabolic Enzymes
Enzyme Polymorphisms Affecting Xenobiotic Toxicity
Inducibility of foreign Compound Metabolic Enzymes
Induction of Enzymes for Health Benefits
Diversity of Metabolic Enzyme Modulators
Dietary Inducers of Detoxification Enzymes.<br>