The Yearbook compiles the most recent, widespread developments of experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in their field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediattrics, intensive care and emergency medicine. (With approximately 90 contributions.)

Host Responses in Sepsis and ARDS

Balancing the Inflammatory Response in Sepsis
Bactericidal/Permeability-Increasing Protein (BPI): Structure, Function, and Clinical Applications
Inhibition of the Activation of Nuclear Factor-?B as a Novel Therapeutic Approach for SIRS and Septic Shock
The Role of the Host Defense Response in the Progression and Outcome of ARDS
The Role of Cytokines in the Pathogenesis of Pneumonia
A Central Role of Interleukin-8 in the Pathogenesis of ARDS
Neutrophil Myeloperoxidase: Effector of Host Defense and Host Damage
NAD(P)H Oxidase in Non-Phagocytic Cells
Gelatinases and Acute Respiratory Distress Syndrome
Cardiocirculatory Alterations
Molecular Mechanisms of Action of Nitric Oxide in Heart Muscle
Development of Myocardial Tolerance to Ischemia/Reperfusion and Septic Injury
Endothelial Cell Dysfunction in Septic Shock
Alterations of Important Regulators of Macro-and Microcirculation in the Critically Ill
Microvascular Regulation of Tissue Oxygenation in Sepsis
Selective Pharmacological Inhibition of Inducible Nitric Oxide Synthase in Experimental Septic Shock
The Use of Dopamine and Norepinephrine in the ICU
Oxygen Carriers
The Red Blood Cell: New Ideas About an Old Friend
Transfusion Requirements in Critical Care: A Multicenter Controlled Clinical Trial
Artificial Oxygen Carriers
Epidemiology and Markers of Sepsis - Clinical Trials
Do We Really Know the Epidemiology and Clinical Course of Sepsis?
Prognostic Markers in Sepsis
Procalcitonin - An Indicator of Sepsis
Is There a Role for Surrogate Markers in the Evaluation of Sepsis Trials
Discourse on Method: Measuring the Value of New Therapies in Intensive Care
Severe Infections
Antimicrobial Therapy for ICU-Acquired Infection: Timefor a Reappraisal
Nosocomial Sinusitis: A Critical Appraisal of the Evidence
The Importance of Initial Empiric Antibiotic Selection in Ventilator-Associated Pneumonia
Why, When, and How to Prescribe a Combination of Antibiotics
Prevention of Infections Associated with Vascular Catheters
Management of Fever in Cancer Patients with Acquired Neutropenia
Measuring Lung Mechanics
Determination of Lung Volume in the ICU
Chest Wall Mechanics: Methods of Measurement and Physiopathologie Insights
Modes of Mechanical Ventilation
Emergency Intubation: The Difficult Airway
Control of Breathing During Assisted Mechanical Ventilation
Proportional Assist Ventilation
Pressure Controlled Ventilation (PCV): The Ideal Mode of Mechanical Ventilation?
The Open Lung Concept
Lung Stretching and Barotrauma
Inflammatory Consequences of High Stretch Lung Injury
Mechanical Ventilation-Induced Injury
Barotraumatic Effects of Mechanical Ventilation
Weaning from Mechanical Ventilation
The Pathophysiology of Weaning Failure
What Have We Learned About Weaning Over the Last Five Years
Non-Invasive Mechanical Ventilation
Non-Invasive Ventilation in Acute Respiratory Failure: Technological Issues
Non-Invasive Nocturnal Mechanical Ventilation: Is it Feasible for COPD Patients?
Lung Perfusion - Inhaled Nitric Oxide
Distribution of Pulmonary Perfusion in Healthy and Injured Lungs
The Administration and Measurement of Nitric Oxide During Mechanical Ventilation
Inspiratory Nitric Oxide Concentration Fluctuation During Inhalational NO Administration
Effects of Inhaled Nitric Oxide on Circulating Blood Cells
Acid-Base - Lactate Metabolism
Recent Advances in Acid-Base Physiology Applied to Critical Care
Pivotal Role of Lactate in Aerobic EnergyMetabolism
Metabolism
Skeletal Muscle in Critical Illness
Metabolic Requirements of the Neurosurgical Patient
Enteral Nutrition in the Critically 111 Patient: A Practical Approach
Immunonutrition in Cancer Surgical Patients
The Gut
Ischemia/Reperfusion of the Gut
Stress Ulceration in the Critically Ill Population
Hemodynamic Management of Gastric Intramucosal Acidosis in Septic Patients
Intra-Abdominal Hypertension and Intensive Care
Head Trauma
Pharmacological Augmentation of Endogenous Neuroprotective Responses after Traumatic Brain Injury
Experimental and Clinical Neuroprotection: An Update
Cerebral Extraction Monitoring in Brain Injury
Surgery and Obstetrics
Pediatric Problems in Heart Surgery
Crises in Pre-Eclampsia
ICU Performance - Evaluation
Performance of the ICU: Are We Able to Measure it?
Evidence-Based Medicine: The Wolf in Sheep's Clothing.